a tool for identifying drug-targetable redox-active disulphides

Beta-defensin 12

Intramolecular

Cysteine 5 and cysteine 34

A redox-regulated disulphide may form within Beta-defensin 12 between cysteines 5 and 34.

Details

Redox score ?

85

PDB code

Structure name

solution structure of bovine neutrophil beta-defensin 12: the peptide fold of the beta-defensins is identical to that of the classical defensins

Structure deposition date

1995-03-08

Thiol separation (Å)

2

Half-sphere exposure sum ?

57

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

5

Residue number B

34

Peptide name

Beta-defensin 12

Ligandability

Cysteine 5 of Beta-defensin 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 34 of Beta-defensin 12

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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